Rodolphe Barrangou – Catching up with the CRISPR Craze | GES Colloquium [Hybrid]
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Catching up with the CRISPR Craze
Nelson 4305 + Zoom | Deploying and commercializing genome editing technologies: challenges, opportunities, and implications of disruptive technologies
The advent of CRISPR-based technologies has revolutionized our ability to manipulate the genetic content of organisms across the tree of life and democratized genome editing across the globe. Repurposed from obscure adaptive immune systems in bacteria, CRISPR molecular machines have been broadly deployed in academia and industry in the past 10 years to manipulate the genomes of organisms relevant to medicine, biotechnology, and agriculture. We now have access to a portable CRISPR toolbox enabling flexible editing from a single nucleotide to large-scale genome manipulation in organisms that span minimalistic viruses to large trees and their corresponding genome range and complexities. So far, most applications focus on the design of efficacious and safe gene and cell therapies to address human disease. Yet, there are un(der)-appreciated opportunities to deploy genome editing modalities for sustainable agriculture, to enhance crops (yield and traits), but also livestock, trees, and organisms used throughout the food supply chain. There is a path to next-generation therapies by 2030, sustainable agriculture by 2040, and breeding healthier forests by 2050. Besides the technical bottlenecks, it is also necessary to account for regulatory frameworks, intellectual property pursuit, public engagement, ethical deployment, consumer acceptance, and geopolitical issues impacting our practical ability to harness genome editing to address medical, agricultural, and environmental challenges that require such disruptive technologies.
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Rodolphe Barrangou, PhD
Distinguished Professor at NC State University | Profile
Rodolphe Barrangou, Ph.D., is the Todd R. Klaenhammer Distinguished Professor at North Carolina State University. Rodolphe spent 9 years in R&D and M&A at Danisco and DuPont, and has been at NC State since 2013.
For his CRISPR work, Rodolphe received several international awards, including the 2016 Canada Gairdner International Award, the 2016 Harvard Medical School Warren Alpert Prize, the 2017 NAS Award in Molecular Biology, and the 2018 NAS Prize in Food and Agriculture Sciences. He has been elected into the National Academy of Sciences, the National Academy of Engineering, the National Academy of Inventors, the American Academy of Arts and Sciences, and the National Inventors Hall of Fame.
Dr. Barrangou earned a BS in Biological Sciences from Rene Descartes University, France, an MS in Biological Engineering from the University of Technology in Compiegne, France, an MS in Food Science from NC State, a PhD in Genomics from NC State, and an MBA from the University of Wisconsin-Madison.
Dr. Barrangou is also the former Chairman of the Board of Caribou Biosciences (NASDAQ CRBU), a co-founder of Intellia Therapeutics (NASDAQ NTLA), Locus Biosciences, TreeCo, Ancilia Biosciences, and CRISPR Biotechnologies, an advisor to Inari Ag, Provaxus, the KiTua fund, and the Editor in Chief of the CRISPR Journal. At NC State, Professor Barrangou holds appointments and affiliations in a dozen departments, academic programs, and centers, supporting the land-grant mission of the University.
The Genetic Engineering and Society (GES) Colloquium is a seminar series that brings in speakers to present and stimulate discussion on a variety of topics related to existing and proposed biotechnologies and their place within broader societal changes.
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